64
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17030 |
Tegoprazan
|
ATPase; Proton pump | Membrane transporter/Ion channel |
Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,能够控制胃酸分泌和运动,在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。 | |||
T22391 |
Omeprazole Sodium
|
P450; Proton pump; Antibacterial; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Omeprazole 是有效的质子泵抑制剂,在胃肠道疾病的研究中具有价值。它竞争性抑制CYP2C19活性,Ki 为 2 到 6 μM。它还抑制革兰氏阴性菌和革兰氏阳性菌生长。它是中性鞘磷脂酶的外泌体抑制剂。 | |||
T10435 |
Linaprazan
利那拉生,AZD0865 |
Potassium Channel | Membrane transporter/Ion channel |
Linaprazan (AZD0865) 通过K+竞争抑制胃中的H+,K+ -ATPase. (IC 50: 1.0 ± 0.2 μM)。Linaprazan 对酸有很强的抑制作用。 | |||
T11191 |
EN6
|
Proton pump; Autophagy | Autophagy; Membrane transporter/Ion channel |
EN6 是一种小分子体内自噬激活剂,其共价靶向溶酶体v-ATP 酶的 ATP6V1A 亚基中的半胱氨酸 277。它以溶酶体依赖性方式清除 TDP-43 聚集体,这是额颞叶痴呆的病原体。它介导的 ATP6V1A 修饰使 v-ATP 酶与 Rags 分离,从而抑制 mTORC1 信号传导、增加溶酶体酸化和激活自噬。 | |||
T20626 |
Esomeprazole
|
Proton pump; Cysteine Protease | Membrane transporter/Ion channel; Proteases/Proteasome |
Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体,抑制溶酶体半胱氨酸蛋白酶legumain,防止癌症转移。它是一种质子泵抑制剂(PPI)。 | |||
T1756L |
Ilaprazole
IY81149,艾普拉唑,IY 81149,IY-81149 |
Proton pump; TOPK | MAPK; Membrane transporter/Ion channel |
Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制H+/K+-ATPase,在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂,用于胃溃疡的研究。 | |||
T8388 |
Vonoprazan
TAK-438 (free base),沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
T9230 |
KM 91104
|
ATPase | Membrane transporter/Ion channel |
KM 91104 是一种细胞通透性 V-ATPase 抑制剂,选择性作用于 V-ATPase 的 a3-b2 亚单位。 | |||
T16682 |
Pumaprazole
BY-841,普马拉唑 |
Proton pump | Membrane transporter/Ion channel |
Pumaprazole (BY-841) 是一种有效的、可逆的质子泵拮抗剂。 | |||
T2188 |
Thonzonium Bromide
嘧苯十六铵,通佐溴胺 |
Proton pump; Antibacterial; Autophagy | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Thonzonium bromide 是一种单阳离子表面活性剂,在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收,并在体内阻止 LPS 诱导的骨丢失。 | |||
T21254 |
Vonoprazan Fumarate
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。 | |||
T1756 |
Ilaprazole sodium
IY-81149 sodium,艾普拉唑钠 |
Proton pump; TOPK | MAPK; Membrane transporter/Ion channel |
Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制 H+/K+-ATPase,在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂,用于胃溃疡的研究。 | |||
T0502 |
Zinc pyrithione
吡硫锌,OM-1563,吡啶硫酮锌 |
Proton pump; Antibacterial; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Zinc pyrithione (OM-1563) 通过阻断质子泵破坏膜转运,具有抗真菌和细菌作用。 | |||
T1651 |
Rabeprazole sodium
Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium |
Apoptosis; Proton pump | Apoptosis; Membrane transporter/Ion channel |
Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂,不可逆地抑制胃 H+/K+-ATPase,可研究胃溃疡和胃食管反流。它诱导细胞凋亡,也抑制尿苷核苷核糖水解酶 ,IC50为 0.3 μM。 | |||
T2686L |
Esomeprazole Sodium
埃索美拉唑钠,(S)-Omeprazole sodium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌,在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T6700 |
Tenatoprazole
泰妥拉唑,TU-199 |
Proton pump | Membrane transporter/Ion channel |
Tenatoprazole (TU-199) 是一种口服有效的,基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+/K+-ATP 酶活性,IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用,抑制几种包膜病毒的产生,包括 EBV。 | |||
T0757 |
Omeprazole
Losec,Prilosec,奥美拉唑,奥美拉挫,H 16868,Antra |
Proton pump; Phospholipase; Antibacterial; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Omeprazole (Losec) 是一种质子泵抑制剂,有研究胃肠道疾病的潜力。它竞争性抑制 CYP2C19活性,Ki 为 2 到 6 μM。它还抑制革兰氏阳性菌和革兰氏阴性菌生长。它是中性鞘磷脂酶的外泌体抑制剂。 | |||
T1734 |
Rabeprazole Sulfide
雷贝拉唑相关物质E,Rabeprazole Related Compound E |
Proton pump; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
Rabeprazole Sulfide (Rabeprazole Related Compound E) 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种质子泵抑制剂类的抗溃疡药物,有效抑制幽门螺旋杆菌的活性,可通过与胃壁细胞中的(H+/K+)-ATPase 相互作用来抑制胃酸分泌,可研究各种消化系统疾病。 | |||
T2686 |
Esomeprazole Magnesium
(S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T0674 |
Lansoprazole
兰索拉唑,A-65006,AG-1749 |
Proton pump; Phospholipase; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Lansoprazole (A-65006) 是一种可抑制胃酸生成的质子泵抑制剂。它是中性鞘磷脂酶的外泌体抑制剂。 | |||
T1021 |
(R)-Lansoprazole
Dexlansoprazole,右旋兰索拉唑,T 168390,TAK 390,R-(+)-Lansoprazole |
Proton pump | Membrane transporter/Ion channel |
(R)-Lansoprazole (T 168390) 是Lansoprazole 的R 型异构体。Lansoprazole 是口服有效的质子泵抑制剂,能抑制胃酸生成。Lansoprazole 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂),能透过血脑屏障。 | |||
T6928 |
Pantoprazole
SKF96022,泮托拉唑,BY1023 |
Apoptosis; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole (BY1023) 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
T8386 |
Esomeprazole Magnesium trihydrate
埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate |
Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T0161 |
Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis; Potassium Channel; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑,是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T6929 |
Pantoprazole sodium
Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc |
Apoptosis; Others; Proton pump; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others |
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T5449 |
Bamaquimast
F 10126,L 0042,巴马司特 |
Proton pump | Membrane transporter/Ion channel |
Bamaquimast (L 0042) 是一种抗哮喘药。 | |||
T29164 |
WY-47766
WY47766 |
||
WY-47766, a proton pump inhibitor, is used potentially for the treatment of postmenopausal osteoporosis. | |||
T12309 |
Omeprazole metabolite Omeprazole sulfone
Omeprazole sulphone,Omeprazole sulfone |
Others | Others |
Omeprazole metabolite Omeprazole sulfone 是Omeprazole 的代谢物,能够抑制质子泵。 | |||
T2687 |
Omeprazole sulfide
Omeprazole metabolite Omeprazole sulfide,Ufiprazole,奥美拉唑硫醚 |
Proton pump; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Omeprazole sulfide (Ufiprazole) 是 Omeprazole 的代谢物。 | |||
T28665 |
Saviprazole
Hoe731,Hoe 731,Hoe-731 |
Proton pump | Membrane transporter/Ion channel |
Saviprazole (Hoe-731) 是一种质子泵抑制剂,可用于治疗胃溃疡。 | |||
T23667 |
AGN-201904
AGN201904,AGN 201904 |
ATPase | Membrane transporter/Ion channel |
AGN-201904 是质子泵抑制剂,是一种奥美拉唑前药,可延缓衰老,可用于预防和治疗消化性溃疡。 | |||
T10138 |
4-Desmethoxy Omeprazole
|
Drug Metabolite | Metabolism |
4-Desmethoxy Omeprazole 是 Omeprazole 的活性代谢物。Omeprazole 是质子泵抑制剂。Omeprazole 竞争性抑制 CYP2C19 活性,Ki=2 - 6 μM。Omeprazole 还抑制革兰氏阴性菌和革兰氏阳性菌生长。 | |||
T21023 |
Bedaquiline fumarate
TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323 |
Antibacterial; Antibiotic | Microbiology/Virology |
Bedaquiline fumarate (TMC207) 是二芳基喹啉抗生素,作用于 ATP 合成酶,常用于结核杆菌感染的研究。 | |||
T20714 |
Levolansoprazole
左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole |
Proton pump | Membrane transporter/Ion channel |
Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂,不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50:82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性,具有相似的效力。 | |||
T10221 |
Abeprazan hydrochloride
DWP14012 hydrochloride,Fexuprazan hydrochloride |
Proton pump | Membrane transporter/Ion channel |
Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂,通过竞争性的与钾离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI),通过减少胃酸的产生而起作用,可用于治疗胃酸相关疾病,如胃食管反流病(GERD)和消化性溃疡。 | |||
T28787 |
SK&F-95601
SK&F 95601,SKF95601,SKF 95601,SKF-95601 |
||
F-95601 is a proton pump inhibitor. | |||
T28794 |
SKF-97574 HCl
SKF97574,SKF-97574,B-9937-051,BY 574,SKF 97574,SK&F-97574 |
||
SKF-97574 is proton pump inhibitor. | |||
T70825 |
TY 11345
|
||
TY 11345 is a proton pump inhibitor. | |||
T68303 | Esomeprazole strontium | ||
Esomeprazole strontium is a gastric proton pump inhibitor. | |||
T70857 | Scopadulciol | ||
Scopadulciol is and enzyme and proton pump inhibitor. | |||
T26727 |
Azeloprazole
E-3710,Z215,E3710,Z 215,E 3710,Z-215 |
||
Azeloprazole, a proton pump inhibitor, is used potentially for the treatment of gastroesophageal reflux disease (GERD). | |||
T11817 | Lansoprazole Sulfide D4 | Proton pump | Membrane transporter/Ion channel |
Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. | |||
T70135 | Nepaprazole sodium dihydrate | ||
Nepaprazole sodium dihydrate is a proton pump inhibitor potentially for treatment of gastric ulcers. | |||
T61445 | Tenatoprazole sodium | ||
Tenatoprazole sodium (TU-199 sodium) is a potent proton pump inhibitor that effectively suppresses the activity of hog gastric H+/K+-ATPase, a vital enzymatic pump involved in acid secretion. It achieves this inhibition at an impressive IC50 value of 6.2 μM. | |||
T68250 | Omeprazole magnesium | ||
Omeprazole magnesium 是口服活性的质子泵(proton pump)抑制剂(PPI),用于抑制胃酸,常用于研究胃酸反流和烧心症相关症状。 | |||
T39583 |
Zastaprazan
|
||
Zastaprazan, a proton pump inhibitor (WO2018008929), is utilized in the research of gastrointestinal inflammatory diseases and conditions related to gastric acid. | |||
T81119 |
S-Pantoprazole sodium trihydrate
|
Proton pump | Membrane transporter/Ion channel |
S-Pantoprazole (sodium trihydrate) 是与Pantoprazole关联的化合物,在调节胃酸分泌相关疾病中起着关键作用,并可作为质子泵 (proton pump) 抑制剂使用。 | |||
T11816 |
Lansoprazole-d4
AG-1749 D4,Lansoprazole D4 |
Proton pump | Membrane transporter/Ion channel |
Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid. | |||
T12308 |
Omeprazole-d3
奥美拉挫 D3,H 16868 D3 |
Others | Others |
Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI) | |||
T14051 |
5-Hydroxylansoprazole
AG1908 |
Proton pump | Membrane transporter/Ion channel |
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, resulting in the formation of 5-Hydroxylansoprazole. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
TN1103 |
Diphyllin
山荷叶素,二叶草素 |
ATPase; Proton pump; Influenza Virus; HIV Protease | Membrane transporter/Ion channel; Microbiology/Virology; Proteases/Proteasome |
Diphyllin 是一种从Justicia procumbens 中分离的芳基萘木脂素,是HIV-1的有效抑制剂,IC50 为 0.38 μM。它是V-ATPase 抑制剂,IC50值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。它抑制NO 产生,IC50值为 50 μM ,具有抗癌和抗炎活性。 | |||
T6740 |
Bafilomycin A1
巴佛洛霉素A1,巴佛洛霉素 A1 |
Apoptosis; Proton pump; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 | |||
T6368 |
Abscisic Acid
Abscisin II,Dormin,(+)-脱落酸,(+)-ABA,Abscisic Acid (Dormin) |
Others; Proton pump; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Others |
Abscisic Acid (Dormin) 是具有口服活性的植物激素,存在于蔬菜和水果中,也是内源性的哺乳动物激素。它是生长抑制剂,可以调节植物生长发育。他抑制质子泵,并导致 Ca2+依赖性的质膜去极化。它是 LANCL2 的天然配体,属于胰岛素敏感化合物,在糖尿病前期,2 型糖尿病和代谢综合征的研究中具有价值。 | |||
T21651 |
Lansoprazole sodium
兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium |
Proton pump; Phospholipase; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Lansoprazole sodium (Lansoprazole (sodium)) 是一种质子泵抑制剂,是中性鞘磷脂酶的外泌体抑制剂,能抑制胃酸生成。 |